If you do drink grapefruit juice, do not take a dapoxetine tablet for at least 24 hours afterwards. Weak pelvic floor muscles might make it harder to delay ejaculation. Rapid ejaculation: a review of conceptual, etiological, and treatment issues. It might take time to find the treatment or combination of treatments that work for you. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome. Dosage, administration, and formulation Oral dapoxetine is indicated for the treatment of men aged 18—64 years with premature ejaculation. Serotonin and premature ejaculation: from physiology to patient management.This paper reviews the current evidence for use of dapoxetine in the treatment of PE in adult men. There is substantial evidence that dapoxetine 30 mg or .  · Background. Premature ejaculation (PE) is the most common male sexual complaint. Off-label oral selective serotonin reuptake inhibitors (SSRIs) are commonly . Clinical Question Are selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) safe and effective for the treatment of .