Definition, prevalence and aetiology of premature ejaculation Definition There are multiple definitions of PE [ American Psychiatric Association, ; Hatzimouratidis et al. These improvements were noted not only at the end-of-study but at all time points in between. Dapoxetine is a selective serotonin reuptake inhibitor medicine which has been specially developed for the treatment of premature ejaculation. This drug treats prostate gland enlargement. Some medications used to treat erectile dysfunction also might help premature ejaculation.DrugBank Accession Number. DB Background. Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. Dapoxetine, marketed as Priligy, among others, is a medication used for the treatment of premature ejaculation (PE) in men 18–64 years old. [3] [4] [5] Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. [6]. This review encompasses studies of dapoxetine pharmacokinetics, animal studies, human phase I, II and III studies, independent postmarketing and pharmacovigilance efficacy and safety studies and drug-interaction studies. Dapoxetine is a potent SSRI which is administered on demand 1–3 h prior to planned sexual contact.

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